Development and design of new 1,2,4-triazole-1-ylmethylazoles- modern highly effective fungicides

Tsaplin Grigory

Mendeleev University of Chemical Technology, Russia

Biography :

Tsaplin Grigory has completed his PhD at the age of 30 years from Mendeleev University of Chemical Technol­ogy (MUCTR). He is the assistant at department of chemistry and technology of organic synthesis of MUCTR. He has published more than 28 papers in reputed journals and 5 RU patents.

Abstract :

In modern medical chemistry and agrochemistry, drugs for the treatment of fungal diseases occupy a special place. The most common and effective class are azoles having the pharma­cophore group imidazole or 1,2,4-triazole. They have a systemic effect and low toxicity. Azoles inhibit lanosterol alpha-demethylase (CYP51Y) and disrupt the permeability of the fungal cell membrane. They are used in clinical practice and are among the top 200 best-selling med­icines. The current work is devoted to the development of a new design of azoles for the treatment of fungal diseases based on 1,2,4-triazole-1-ylmethylazoles with a characteristic change in the structure of active substances from branched to elongated type. Methods for obtaining new series of compounds have been developed and their high efficiency in biolog­ical tests in vitro has been shown. This report covers the work result over the past 5 years.