Synthesis of azole derivatives based on 1,2,3-dithiazoles with fungicidal activity

Elizaveta Bashkalova

Mendeleev University of Chemical Technology, Russia

Biography :

Elizaveta is a 5th year student at the Mendeleev University of Chemical Technology and has been actively en­gaged in the chemistry of heterocycles, in particular azoles, for three years. She has published two scientific papers and actively participates in conferences at various levels.

Abstract :

Fungicidal drugs are widely used in agriculture and in medical chemistry. Azoles can be at­tributed to such drugs with a systemic effect. Many drugs include several heterocyclic ele­ments, which makes it possible to enhance the fungicidal effect of the compounds. It is known that 1,2,3-dithiazole derivatives have a wide range of biological activity. For the first time, we obtained compounds based on the initial Appel salt, the structure of which contains both a dithiazole fragment and a functional group of cyanothioanilides, a fragment of the collapse of the heterocyclic ring. The high fungicidal activity of target compounds and intermediate 4-chloro-N-aryl-1,2,3-dithiazole-5-imines was shown in vitro tests vs six species of phyto­pathogenic fungi.