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Chronic fatigue syndrome and myalgia encephalomyelitis: a literature review on management principles and emerging therapies

2nd International Conference on Dermatology & Skincare

08-09, May 2025 | Boston, USA

Vaidya Bala

The Wollongong Hospital, Australia

Abstract :

Chronic Fatigue Syndrome (CFS), also known as Myalgia Encephalomyelitis (ME), is charac­terized by severe, persistent fatigue lasting more than six months, which is not alleviated by rest and significantly reduces previous levels of activity (Centres for Disease Control and Pre­vention [CDC], 2023). The Institute of Medicine (IOM) criteria require the presence of post-ex­ertional malaise (PEM), unrefreshing sleep, and either cognitive impairment or orthostatic intolerance (CDC, 2023).

The aetiology of CFS/ME is multifactorial, involving genetic predisposition, infections, immune system dysfunction, endocrine system abnormalities, and psychological factors (MSD Man­uals, 2023; Verywell Health, 2023). Pathogenesis includes neuroinflammation, mitochondrial dysfunction, oxidative stress, autonomic nervous system dysfunction, and gut microbiome al­terations (Oxford Academic, 2023; Springer, 2023).

Effective symptom management includes pacing and energy management, cognitive behav­ioral therapy (CBT), symptom-specific medications, diet and nutrition, physical therapy, sleep hygiene, stress management, support systems, assistive devices, and regular medical check-ups (National Institute for Health and Care Excellence [NICE], 2023; National et al. [NHS], 2023; Verywell Health, 2023; Sleep Foundation, 2023).

Rehabilitation focuses on pacing and energy management, CBT, graded exercise thera­py (GET), symptom management, psychological support, and a multidisciplinary approach (NICE, 2023; BMJ, 2023). Emerging therapies like neuromodulation and ongoing pharmaco­logical research are also being explored (Cambridge et al., 2023).

Biography :

Vaidya Bala is a Medical Co-Director for Population and Public Health at the Illawarra and Shoalhaven Local Health District Hospitals and a Senior Staff Specialist in Rehabilitation Medicine at The Wollongong Hospital, Wollongong, NSW, Australia. He is pursuing a Population Health Doctorate at Campbell University, NC, USA. He has published 12 papers in international peer-reviewed journals and presented at various international confer­ences since 2005.He is currently an examiner with the Royal Australasian College of Physicians for the Faculty of Rehabilitation Medicine and a Senior lecturer at the University of Wollongong.