From waste to Wellness: Impact of Fiber-Rich Brewer’s spent grain on glycemia and insulinemia

Hammad Ullah

University of Naples Federico II, Italy

Biography :

Hammad Ullah obtained his PhD degree in 2023 and is currently working as a Postdoctoral fellow, both at the University of Naples Federico II Italy. His research activity focuses mainly on the comprehensive investigation of natural products, with the final aim of the development of new food supplements and functional food ingre­dients. He has authored more than 60 articles, 1 book, and 7 book chapters. His work has been recognized for its significance by MEDWELL Award for Best PhD Thesis (2023), PSE Dra. Mariola Macías Award (2023), Young Research Award at MONASH INITIATE 2022, and Best Oral Presentation Award at 1-EuSPMF, Serbia (2022).

Abstract :

Dietary fibers improve human health by lowering the risk factors for metabolic disorders, including hyperglycemia, hyperinsulinemia, insulin resistance, and hypercholesterolemia. To this end, a monocentric, randomized, cross-over, double-blind, placebo-controlled clinical trial is designed to assess the hypoglycemic and hypoinsulinemic response of fibers-enriched food supplement based on brewer’s spent grain (BSG) in subjects with slightly impaired glu­cose tolerance. The chemical analysis of BSG extract showed the presence of bioaccessible ferulic acid (91.3mg/100g), resistant starch (14.64g/100g), arabinoxylans (7.50g/100g), β-glu­cans (1.92g/100g), and other soluble fibers (6.43g/100g). In a cross-over clinical design, 40 normoglycemic patients were randomly assigned to one of two groups (n = 20, each), supple­mented with food supplement or placebo. Postprandial blood glucose levels were significant­ly lower in food supplement group as compared to placebo, after 90 and 120 minutes of the treatment; nevertheless, the two glycemic curves overlapped substantially at baseline and in the first 60 minutes. The clinical outcome was supported by the considerable decrease in postprandial insulinemia in subjects supplemented with BSG extract. No adverse effects were reported with the food supplement by enrolled subjects. In conclusion, this study demonstrat­ed improved glucose metabolism and insulinemic response with BSG extract supplementa­tion in normoglycemic subjects with mild insulin resistance.