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Cognitive decline and sarcopenia: An in-depth bibliometric analysis of their associations and viable intervention targets

2nd International Conference on Dementia and Brain Disorders & 3rd International Conference on Neurology & Neurological Disorders

November 06-07, 2025 | London, UK

Xiaolei Liu

Sichuan University, China

Abstract :

Cognitive decline and sarcopenia are age-related conditions that are closely related be­cause of their close interaction and etiological factors. The presence of sarcopenia can in­fluence changes in cognitive status. Given their potentially adverse outcomes, it is crucial to investigate their associations to develop effective intervention and management strategies for geriatric patients. In this study, we screened the Web of Science core collection database for literature on sarcopenia and cognitive decline over the past 30 years. Bibliometric analysis was conducted to ascertain the link between them. On the basis of the inclusion and exclusion criteria, 1426 literature sources were selected for further analysis. Keywords such as “age” and “predictor” represent current and potential future research trends in this field. Additionally, potential targets involved in pathways related to cellular aging and muscular metabolism regulation, including the AMPK, PI3K-Akt, and longevity-regulating pathways, were identified between the two diseases. This study established a close correlation between cognitive de­cline and sarcopenia in terms of pathogenesis, prevention, and treatment measures, laying the groundwork for exploring shared strategies to address these disorders.

Keywords: Cognitive decline, Sarcopenia, Association, Bibliometric analysis.

Biography :

Xiaolei Liu is a distinguished medical professional based in Chengdu, China. Affiliated with West China Hospital, Sichuan University, Dr. Liu contributes significantly to clinical practice and research in their field. With a com­mitment to advancing healthcare and medical science, Dr. Liu actively engages in academic and professional collaborations