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Successful healing of chronic venous ulcer using zinc oxide nanoparticles and compression therapy in a 75-year-old Syrian female: a case report

2nd Global Event on Materials Science and Engineering & 2nd World Congress on Nanotechnology

November 06-07-2025 | HYBRID EVENT

Hiba Shreiki

Tishreen university, Syria

Abstract :

Introduction: Chronic venous disease is a commonly underdiagnosed condition that grad­ually diminishes a patient’s quality of life and imposes a growing burden on healthcare re­sources. Venous leg ulcers (VLUs) arise as a complication of chronic venous insufficiency and represent the most prevalent type of slow-healing wound in the lower extremities.

Case presentation: In this case report, we present the successful treatment of a 75-year-old woman with a chronic venous ulcer caused by chronic deep venous insufficiency. The patient had been struggling with an unresponsive venous leg ulcer for 7 years with no improvement from previous treatments. A three-layer Unna boot treatment, including (ZnO NPs) and a two-component compression system was applied, and significant ulcer reduction was ob­served.

Discussion: ZnO NPs impregnated bandages, like those found in an Unna boot, offer com­pression by wrapping gauze dressing impregnated with ZnO NPs around the patient’s leg forming a semi-solid mold around the extremity. A more efficient treatment approach could lead to fewer clinic visits, thereby reducing healthcare expenses by enhancing the method of managing venous ulcers through a combination of compression and simple, cost-effec­tive surface dressing materials. It’s worth noting that ZnO NPs have demonstrated significant benefits for wound healing.

Conclusion: Utilizing ZnO NPs alongside compression therapy has proven highly effective, accelerating healing and offering a cost-effective solution. Further research is needed to study the safety of ZnO NPs.

Biography :

Hiba Shreiki has a Bachelor’s degree in Pharmacy and Pharmaceutical Chemistry from Latakia University, Syria. Her research interests focus on environmental health, public health, and developing effective solutions in con­flict-affected areas. She has experience working as a medical representative for international companies in Syr­ia, which enriched her understanding of healthcare challenges in complex settings. She has published research on nanotechnology and public health, and she is currently engaged in research projects aimed at improving public health education.